Biography:
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
SCHOOL OF MEDICINE
PUBLIC RELATIONS
Leonard Hayflick, Ph.D.
Professor of Anatomy
University of California, San Francisco
School of Medicine
P.O. Box 89
The Sea Ranch, CA 95497
Summary Biography (Jan-03)
Dr. Hayflick was born on 20 May 1928 in Philadelphia, Pa. His formal higher education was
obtained at the University of Pennsylvania where he received the Ph.D. in 1956. After
receiving a post-doctoral Fellowship for study at the University of Texas, Galveston, he
returned to Philadelphia, where he spent ten years as an Associate Member of the Wistar
Institute and two years as an Assistant Professor of Research Medicine at the University
of Pennsylvania.
In 1968 Dr. Hayflick was appointed Professor of Medical Microbiology at the Stanford
University School of Medicine, Stanford, California. In 1982 he moved to the University of
Florida, Gainesville, where he became Director of the Center for Gerontological Studies
and Professor of Zoology in the College of Liberal Arts and Sciences and Professor of
Microbiology and Immunology in the College of Medicine.
In 1988 Dr. Hayflick joined the faculty of the University of California, San Francisco
where he is presently Professor of Anatomy. Dr. Hayflick is a member of numerous national
and international scientific and public boards of directors and committees. He is now, or
has been, on the Editorial Boards of more than ten professional journals. Dr. Hayflick was
Editor-in-Chief of the international journal EXPERIMENTAL GERONTOLOGY for 13
years.
He is a member of twenty scientific and professional societies in which he has held
several high offices including President of the Gerontological Society of America from
1982 to 1983. He was a founding member of the Council of the National Institute on Aging,
NIH and Chairman of its Executive Committee. He was a consultant to the National
Cancer Institute, the World Health Organization and is now a member of several scientific
advisory boards and study sections. He was Chairman of the Scientific Review Board of the
American Federation for Aging Research where he was also a Vice President and is now a
Member of the Board of Directors.
Dr. Hayflick is best known for his research in cell biology and mycoplasmology where he
discovered that, contrary to what was believed since the turn of the century, cultured
normal human and animal cells have a limited capacity for replication. This phenomenon is
known as The Hayflick Limit. This discovery, in 1962, overturned a dogma that
existed since early in this century and focused attention on the cell as the fundamental
location of age changes. Dr. Hayflick demonstrated for the first time that mortal and
immortal mammalian cells existed. This distinction is the basis for much of modern cancer
research.
Dr. Hayflick developed the first normal human diploid cell strain for studies on human
aging and for research use throughout the world wherever a normal human cell is required.
One cell strain, developed by Dr. Hayflick and called WI-38, is the most widely used and
highly characterized normal human cell population in the world. Hayflick produced the
first oral polio vaccine made on a continuously propagable cell strain. WI-38 is now used
for the production of all of the Rubella Virus vaccine used in the Western Hemisphere.
WI-38, or its imitators, is used today for the manufacture of most human virus vaccines
produced throughout the world including those for poliomyelitis, rubella, rubeola, rabies
and adenoviruses. Over 750 million vaccinees have received vaccines produced on WI-38 or
similar diploid cell strains.
Dr. Hayflick is also known for his discovery of the cause of primary atypical pneumonia
(Walking Pneumonia) in humans. The etiological agent was first thought to be a
virus, but Dr. Hayflick showed that it was, in fact, a mycoplasma, a member of the
smallest free-living class of microorganisms. The etiological agent was named by him as
Mycoplasma pneumoniae, and was first grown by Hayflick on a medium he developed and that
bears his name. It is now used world wide for mycoplasma isolation and research.
Dr. Hayflick is the recipient of more than twenty-five major awards including the $20,000
Brookdale Award and the Kleemeier Award from the Gerontological Society of America, the
Biomedical Sciences and Aging Award from the University of Southern California, The Karl
August Forster Lectureship of the Academy of Sciences and Literature and the University of
Mainz, Germany, the Samuel Roberts Nobel Foundation Research Recognition Award, the
Lifetime Achievement Award of the Society for In Vitro Biology, the Sandoz Prize from the
International Association of Gerontology, and the Presidential Award from the
International Organization of Mycoplasmology.
In 1997, Hayflick was elected Academician and Foreign Member of the Ukrainian Academy of
Medical Sciences. In 1998 he was elected corresponding member of the Société de Biologie
of France. In 1999 he was presented with the van Weezel Award by the European Society for
Animal Cell Technology and the Lord Cohen of Birkenhead Medal by the British Society for
Research on Aging. In 1997 the American Aging Association established an Annual Hayflick
Lecturship. A second Annual Hayflick Lecture also was established in 2000 by the
University of Alabama, Birmingham. Hayflick is the recipient of the year 2001, $10,000
Life Extension Prize and Laureate Diploma from the Regenerative Medicine Secretariat for
his "..discovery of the finite replicative capacity of normal human diploid
cells.."
Hayflick is a Fellow of the American Association for the Advancement of Science, an
Honorary Member of the Tissue Culture Association and, according to the Institute of
Scientific Information, is one of the most cited contemporary scientists in the world in
the fields of biochemistry, biophysics, cell biology, enzymology, genetics and molecular
biology. Dr. Hayflick is the author of over 250 scientific papers, book chapters and
edited books of which four papers are among the 100 most cited scientific papers of the
two million papers published in the basic biomedical sciences from 1961 to 1978.
Dr. Hayflick is the author of the popular book, How and Why We Age published
in August 1994 by Ballantine Books, NYC and available in 1996 as a paperback. This book
has been translated into nine languages and is published in Japan, Brazil, Russia, Spain,
Germany, the Czech Republic, Poland, Israel and Hungary. It was a selection of The
Book-of-the-Month Club.