Aubrey D.N.J. de Grey
CURRICULUM
VITAE
Name:
Dr. Aubrey D.N.J. de
Grey
Current
post: Chief Science Officer, SENS
Research Foundation
Research
area: the role and causes of all
the accumulating and eventually pathogenic molecular and cellular
side-effects of metabolism that constitute mammalian aging; the
design of interventions to reverse and/or obviate this
accumulation.
Bio
paragraph (e.g., if you have invited me to speak and are creating
promotional material):
Dr. Aubrey de Grey
is a biomedical gerontologist based in Cambridge, UK and Mountain
View, California, USA, and is the Chief Science Officer of SENS
Research Foundation, a California-based 501(c)(3) charity dedicated to
combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the
world’s highest-impact peer-reviewed journal focused on intervention
in aging. He received his BA and Ph.D. from the University of
Cambridge in 1985 and 2000 respectively. His original field was
computer science, and he did research in the private sector for six
years in the area of software verification before switching to
biogerontology in the mid-1990s. His research interests encompass
the characterisation of all the
accumulating and eventually pathogenic molecular and cellular
side-effects of metabolism (“damage”) that constitute mammalian
aging and the design of interventions to repair and/or obviate that
damage. He has developed a possibly comprehensive plan for such
repair, termed Strategies for Engineered Negligible Senescence
(SENS), which breaks aging down into seven major classes of damage
and identifies detailed approaches to addressing each one. A key
aspect of SENS is that it can potentially extend healthy lifespan
without limit, even though these repair processes will probably
never be perfect, as the repair only needs to approach perfection
rapidly enough to keep the overall level of damage below pathogenic
levels. Dr. de Grey has termed this required rate of improvement of
repair therapies “longevity escape velocity”. Dr. de Grey is a
Fellow of both the Gerontological Society of America and the
American Aging Association, and sits on the editorial and scientific
advisory boards of numerous journals and organisations.
Tel.: +44 1223 366197 or +1
650 938 6100
Email:
aubrey@sens.org
Date of
birth: 20th April,
1963
Nationality:
British
Marital
status: Married to Dr. Adelaide T.C.
Carpenter; no children
Education:
B.A. (1985), M.A. (1988) and
Ph.D. (2000), University of Cambridge, Cambridge,
UK
Past
employment:
1985-1986: Sinclair
Research, Cambridge, UK
1986-1992: Man-Made Minions,
Cambridge, UK
1992 (Jan-Oct): EO Computer,
Cambridge, UK
1992-2006: Department of
Genetics, University of Cambridge, Cambridge, UK
2003-2009: Chairman and
Chief Science Officer, Methuselah Foundation
Honours:
2003: Gerontological Society
of America: Fellow
2004: World Transhumanist
Association: H.G. Wells Award
2005: American Aging
Association: Fellow
Society
memberships:
American Aging Association
(member of board of directors, 2002-2007 and
2010-present)
International Association of
Biomedical Gerontology (chair, 2003-2005)
British Society for Research
on Ageing (member of board of directors,
2003-2006)
Gerontological Society of
America
International Coenzyme Q10
Association
Mitochondrion Research
Society
Scientific
advisory boards (unpaid):
Maximum Life
Foundation
Legendary
Pharmaceuticals
Centenarian Species and
Rockfish Project
Alcor Life Extension
Foundation
Singularity Institute for
Artificial Intelligence
Foresight
Institute
Biomind
Lifeboat
Foundation
Humanity+
Campaign for Aging
Research
Conferences
organised:
Euromit 4, Cambridge, UK,
September 1999 (co-organiser)
Strategies for Engineered
Negligible Senescence, 1st roundtable, Oakland, CA, USA,
October 2000
Strategies for Engineered
Negligible Senescence, 2nd roundtable, Los Angeles, CA,
USA, Aug. 2001
Strategies for Engineered
Negligible Senescence, 3rd roundtable, Cambridge, UK,
December 2002
International Association of
Biomedical Gerontology, 10th Congress, Cambridge, UK,
Sept. 2003
Strategies for Engineered
Negligible Senescence, 4th roundtable, Bethesda, MD, USA,
July 2004
Strategies for Engineered
Negligible Senescence, 2nd conference, Cambridge, UK,
September 2005
Strategies for Engineered
Negligible Senescence, 3rd conference, Cambridge, UK,
September 2007
Understanding Aging:
Biomedical and Bioenginering Approaches, Los Angeles, USA, June
2008
Strategies for Engineered
Negligible Senescence, 4th conference, Cambridge, UK,
September 2009
Strategies for Engineered
Negligible Senescence, 5th conference, Cambridge, UK,
September 2011
Strategies for Engineered
Negligible Senescence, 6th conference, Cambridge, UK,
September 2013
Journal editorial board
memberships:
Rejuvenation Research
(editor-in-chief)
Disruptive Science and
Technology (executive editor)
Mitochondrion (associate
editor)
AGE – Journal of the American
Aging Association
Current Stem Cell Research &
Therapy
Current Gerontology and Geriatrics
Research
Publications:
- Articles in peer-reviewed
journals:
de Grey ADNJ. A
proposed refinement of the mitochondrial free radical theory of
aging. BioEssays 1997; 19(2):161-166.
de Grey ADNJ. A
mechanism proposed to explain the rise in oxidative stress during
aging. J Anti-Aging Med 1998; 1(1):53-66.
de Grey ADNJ.
Incorporation of transmembrane hydroxide transport into the
chemiosmotic theory. Bioelectrochem Bioenerg 1999;
49(1-2):43-50.
de Grey ADNJ. The
non-correlation between maximum longevity and enzymatic antioxidant
levels among homeotherms; implications for retarding human aging. J
Anti-Aging Med 2000; 3(1):25-36.
de Grey ADNJ. The
reductive hotspot hypothesis: an update. Arch Biochem Biophys 2000;
373(1):295-301.
de Grey ADNJ. Mitochondrial gene
therapy: an arena for the biomedical use of inteins. Trends
Biotechnol 2000; 18(9):394-399.
de Grey ADNJ. A
proposed mechanism for the lowering of mitochondrial electron leak
by caloric restriction. Mitochondrion 2001;
1(2):129-139.
de Grey ADNJ. UK
research on the biology of aging. Exp Gerontol 2001;
37(1):1-7.
de Grey ADNJ, Ames
BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJM, Stock
G. Time to talk SENS: critiquing the immutability of human aging.
Annals NY Acad Sci 2002; 959:452-462.
de Grey ADNJ. The
reductive hotspot hypothesis of mammalian aging: membrane metabolism
magnifies mutant mitochondrial mischief. Eur J Biochem 2002;
269(8):2003-2009.
de Grey ADNJ.
HO2: the forgotten radical. DNA Cell Biol 2002;
21(4):251-257.
de Grey ADNJ, Baynes JW, Berd D, Heward
CB, Pawelec G, Stock G. Is human aging still mysterious enough to be
left only to scientists? BioEssays 2002;
24(7):667-676.
de Grey ADNJ. Bioremediation meets
biomedicine: therapeutic translation of microbial catabolism to the
lysosome. Trends Biotechnol 2002; 20(11):452-455.
de Grey ADNJ. An engineer’s approach to
the development of real anti-aging medicine. Science’s SAGE KE 2003;
2003(1):vp1.
de Grey ADNJ.
Challenging but essential targets for genuine anti-ageing drugs.
Expert Opin Therap Targets 2003; 7(1):1-5.
de Grey ADNJ.
Critique of the demographic evidence for “late-life non-senescence”.
Biochem Soc Trans 2003; 31(2):452-454.
de Grey ADNJ. UK
research on the biology of aging – the next ten years. Lifespan
2003; 11(1):1-4.
de Grey ADNJ. A
hypothesis for the minimal overall structure of the mammalian plasma
membrane redox system. Protoplasma 2003;
221(1-2):3-9.
de Grey ADNJ. The foreseeability of real
anti-aging medicine: focusing the debate. Exp Gerontol 2003;
38(9):927-934.
de Grey ADNJ. Falsifying falsifications:
the most critical task of theoreticians in biology. Med Hypoth 2004;
62(6):1012-1020.
de Grey ADNJ. Escape velocity: why the
prospect of extreme human life extension matters now. PLoS Biol 2004;
2(6):723-726.
de Grey ADNJ, Campbell FC, Dokal I,
Fairbairn LJ, Graham GJ, Jahoda CAB, Porter ACG. Total deletion of
in vivo telomere elongation capacity: an ambitious but possibly
ultimate cure for all age-related human cancers. Annals NY Acad Sci
2004; 1019:147-170.
de Grey ADNJ. Biogerontologists’ duty to
discuss timescales publicly. Annals NY Acad Sci 2004;
1019:542-545.
de Grey ADNJ. Inter-species therapeutic
cloning: the looming problem of mitochondrial DNA and two possible
solutions. Rejuvenation Res 2004; 7(2):95-98.
de Grey ADNJ. The unfortunate influence
of the weather on the rate of aging: why human caloric restriction
or its emulation may only extend life expectancy by 2-3 years.
Gerontology 2005; 51(2):73-82.
de Grey ADNJ. Forces maintaining
organellar genomes: is any as strong as genetic code disparity or
hydrophobicity? BioEssays 2005;
27(4):436-446.
de Grey ADNJ. Whole-body interdiction of
lengthening of telomeres: a proposal for cancer prevention. Front
Biosci 2005; 10:2420-2429.
de Grey ADNJ. Reactive oxygen species production in the mitochondrial
matrix: implications for the mechanism of mitochondrial mutation
accumulation. Rejuvenation Res 2005; 8(1):13-17.
de Grey ADNJ. Resistance to debate on
how to postpone ageing is delaying progress and costing lives. EMBO
Rep 2005; 6(S1):S49-S53.
de Grey ADNJ, Alvarez PJJ, Brady RO,
Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR.
Medical bioremediation: prospects for the application of microbial
catabolic diversity to aging and several major age-related diseases.
Ageing Res Rev 2005; 4(3):315-338.
de Grey ADNJ. Life extension, human
rights, and the rational refinement of repugnance. J Med Ethics
2005; 31(11):659-663.
de Grey ADNJ. A
strategy for postponing aging indefinitely. Stud
Health Technol Inform 2005; 118:209-219.
de Grey ADNJ. The plasma membrane redox
system: a candidate source of aging-related oxidative stress. AGE J
Am Aging Assoc 2005; 27(2):129-138.
de Grey ADNJ. Appropriating microbial
catabolism: a proposal to treat and prevent neurodegeneration.
Neurobiol Aging 2006; 27(4):589-595.
de Grey ADNJ. Extrapolaholics Anonymous:
why demographers’ rejections of a huge rise in cohort life
expectancy in this century are overconfident. Annals NY Acad Sci
2006; 1067:83-93.
de Grey ADNJ. Foreseeable pharmaceutical
repair of age-related extracellular damage. Curr Drug Targets 2006;
7(11):1469-1477.
de Grey ADNJ. Free
radicals in aging: causal complexity and its biomedical
implications. Free Radic Res 2006; 40(12):1244-1249.
de Grey ADNJ. The
urgency dilemma: is life extension research a temptation or a test?
Update 2006; 21(1):6-10.
de Grey ADNJ. The
natural biogerontology portfolio: “defeating aging” as a multi-stage
ultra-Grand Challenge. Annals NY Acad Sci 2007;
1100:409-423.
de Grey ADNJ.
Protagonistic pleiotropy: why cancer may be the only pathogenic
effect of accumulating nuclear mutations and epimutations in aging.
Mech Ageing Dev 2007; 128(7-8):456-459.
Phoenix CR, de
Grey ADNJ. A model of aging as accumulated damage matches observed
mortality patterns and predicts the life-extending effects of
prospective interventions. AGE 2007;
29(4):133-189.
de Grey ADNJ.
Calorie restriction, post-reproductive lifespan and programmed
aging: a plea for rigour. Annals NY Acad Sci 2007;
1119:296-305.
de Grey ADNJ.
Alzheimer’s, atherosclerosis, and aggregates: A role for bacterial
degradation. Nutr Rev 2007; 65(12 Pt.
2):S221-S227.
de Grey ADNJ. Life
span extension research and public debate: societal considerations.
Studies in Ethics, Law and Technology 2007;
1(1):5.
de Grey ADNJ. Our
right to life. J Evol Technol 2008; 17(2):53-57.
de Grey ADNJ. The
singularity and the Methuselarity: similarities and differences.
Stud Health Technol Inform 2009; 149:195-202.
de Grey ADNJ.
Making sure that health and wealth keep pace with extended life
expectancy. United Academics Magazine 2012; 2012(April/May):
http://www.united-academics.org/magazine/17748/making-sure-that-health-and-wealth-keep-pace-with-extended-life-expectancy/
de Grey ADNJ.
Zeno’s paradox and the faith that technological game-changers are
impossible. Gerontology 2012, in press.
Zealley BJ, de
Grey ADNJ. Strategies for engineered negligible senescence (SENS).
Gerontology 2012, in press.
- Reviews and
commentaries:
de Grey ADNJ. More
on mitochondria and senescence: Response to Gershon. BioEssays 1997;
19(6):534-534.
de Grey ADNJ.
Review of Cadenas E and Packer L (eds), “Understanding the Process
of Aging: The Roles of Mitochondria, Free Radicals, and
Antioxidants”. J Anti-Aging Med 1999; 2(3):291.
de Grey ADNJ.
Review of Harman D, Holliday R and Meydani M (eds), “Towards
Prolongation of the Healthy Life Span: Practical Approaches to
Intervention”. J Anti-Aging Med 1999; 2(3):292.
de Grey ADNJ.
Popular gerontology comes of age. Review of Kirkwood TBL, “Time of
our Lives”. BioEssays 1999; 21(9):802-803.
de Grey ADNJ.
Biologists abandon Popper at their peril. BioEssays 2000;
22(2):206-207.
de Grey ADNJ. The
function of mitochondrial dysfunction in aging. J Anti-Aging Med
2000; 3(1):109-112.
de Grey ADNJ.
Review of Asard H, Berczi A and Caubergs RJ (eds), “Plasma Membrane
Redox Systems and Their Role in Biological Stress and Disease”.
Antioxid Redox Signal 2000; 2(2):371-372.
de Grey ADNJ.
Redox 2000: the 5th international conference on plasma membrane
redox systems and their role in biological stress and disease.
Antioxid Redox Signal 2000; 2(2):373-374.
de Grey ADNJ.
Review of Scheffler I, “Mitochondria”. J Am Aging Assoc 2000;
23(4):255.
de Grey ADNJ.
Antioxidants and redox signaling: Internet resources. Antioxid Redox
Signal 2000; 2(4):937-940.
de Grey ADNJ.
Gerontologists and the media: the dangers of over-pessimism.
Biogerontology 2000; 1(4):369-370.
de Grey ADNJ.
Review of Wickens A, “The Causes of Aging”. Exp Gerontol 2000;
34(8):1017-1018.
de Grey ADNJ.
Response to “telomere shortening with aging in human liver”. J
Gerontol A Biol Sci Med Sci 2001; 56(6):B237-B238.
de Grey ADNJ.
Response to “approaches and limitations to gene therapy for
mitochondrial diseases,” Antioxid. Redox Signal. 2001;3:451-460.
Antioxid Redox Signal 2001; 3(6):1153-1155.
de Grey ADNJ.
Review of Finch CE and Kirkwood TBL, “Chance, development, and
aging”. Exp Gerontol 2001; 36(10):1783-1785.
de Grey ADNJ.
Nature of the aging process - Open discussion. Annals NY Acad Sci
2002; 959:463-465.
de Grey ADNJ,
Gavrilov L, Olshansky SJ, Coles LS, Cutler RG, Fossel M, Harman SM.
Antiaging technology and pseudoscience. Science 2002;
296(5568):656.
de Grey ADNJ.
Three detailed hypotheses implicating oxidative damage to
mitochondria as a major driving force in homeotherm aging. Eur J
Biochem 2002; 269(8):1995.
de Grey ADNJ.
Review of Nicholls DG and Ferguson SJ, “Bioenergetics 3”.
Mitochondrion 2002; 2(3):211-213.
de Grey ADNJ. Fear
of misrepresentation cannot justify silence about foreseeable
life-extension biotechnology. BioEssays 2003;
25(1):94-95.
de Grey ADNJ.
Overzealous maximum-likelihood fitting falsely convicts the slope
heterogeneity hypothesis. Exp Gerontol 2003;
38(8):921-923.
de Grey ADNJ.
Review of Mattson MP and Van Zant G (eds), “Stem Cells: A Cellular
Fountain of Youth”. Exp Gerontol 2003;
38(9):1025-1026.
de Grey ADNJ.
Breathtaking biomedical blind spots. Review of Guarente L, “Ageless
Quest”. BioEssays 2004; 26(1):108-109.
de Grey ADNJ.
Models on trial: falsifying overstated claims of generality does not
falsify correctly-stated ones. Exp Gerontol 2004;
39(3):453.
de Grey ADNJ.
Mitochondria in homeotherm aging: will detailed mechanisms
consistent with the evidence now receive attention? Aging Cell 2004;
3(2):77.
de Grey ADNJ. Report of open discussion on
the future of life extension research. Annals NY Acad Sci 2004;
1019:552-553.
de Grey ADNJ.
Welcome to Rejuvenation
Research. Rejuvenation Res 2004; 7(1):1-2.
de Grey ADNJ. Leon
Kass: quite substantially right. Rejuvenation Res 2004;
7(2):89-91.
de Grey ADNJ.
Three self-evident life-extension truths. Rejuvenation Res 2004;
7(3):165-167.
de Grey ADNJ. Mitochondrial mutations in
mammalian aging: an over-hasty about-turn? Rejuvenation Res 2004;
7(3):171-174.
de Grey ADNJ. Meeting report:
Regenerate 2004: tissue engineering the human body, June
10-12, 2004, Seattle.
Rejuvenation Res 2004; 7(3):226-228.
de Grey ADNJ.
Aging, childlessness, or overpopulation: the future’s
right to choose. Rejuvenation Res 2004;
7(4):237-238.
de Grey ADNJ. Meeting report:
8th International Symposium on the Maillard Reaction.
Charleston, South Carolina, August 28-September 1 2004. Rejuvenation Res 2004;
7(4):257-260.
de Grey ADNJ.
When and where to publish important findings: a casualty
of biogerontology’s rise to respectability.
Rejuvenation Res 2005; 8(1):1-2.
de Grey ADNJ. “The rate of aging”: a counterproductively undefinable
term. Rejuvenation Res
2005; 8(2):77-78.
de Grey ADNJ. The
ethical status of efforts to postpone aging: a reply to
Hurlbut. Rejuvenation
Res 2005; 8(3):129-130.
de Grey ADNJ. The SENS Challenge:
$20,000 says the foreseeable defeat of aging is not laughable. Rejuvenation Res 2005;
8(4):207-210.
de Grey ADNJ. Meeting report: International Association of Biomedical Gerontology, 11th
Congress, 13th-16th August, 2005, Aarhus, Denmark. Rejuvenation Res 2005;
8(4):264-266.
de Grey ADNJ. Like
it or not, life extension research extends beyond biogerontology.
EMBO Reports 2005; 6(11):1000.
de Grey ADNJ.
Compression of morbidity: the hype and the reality, part
1. Rejuvenation Res
2006; 9(1):1-2.
de Grey ADNJ. Compression of morbidity: the hype and the reality, part
2. Rejuvenation Res
2006; 9(2):167-168.
de Grey ADNJ. Has Hippocrates had
his day? Rejuvenation Res 2006;
9(3):371-373.
de Grey ADNJ. SENS survives the
Challenge; now let’s get to work.
Rejuvenation Res 2006;
9(4):429-430.
de Grey ADNJ. Is SENS a farrago?
Rejuvenation Res 2006; 9(4):436-439.
de Grey ADNJ. SENS
is hard, yes, but not too hard to try: a reply to Warner.
Rejuvenation Res 2006; 9(4):443-445.
de Grey ADNJ.
Aging and airborne HIV: a reassuring analogy. Rejuvenation Res 2007;
10(1):1-3.
de Grey ADNJ. New
developments at Rejuvenation
Research: high impact factor, advance online publication and
more. Rejuvenation Res 2007; 10(2):125-126.
de Grey ADNJ. The
case for prioritising research on late-onset life-extension
interventions in mammals. Rejuvenation Res 2007;
10(3):257-259.
de Grey ADNJ.
Edmonton: a future center for pioneering biomedical
gerontology? Rejuvenation Res 2007;
10(3):345-347.
de Grey ADNJ.
The need to debalkanize gerontology: a case
study. Rejuvenation Res 2007;
10(4):431-434.
de Grey ADNJ.
Understanding and tackling aging: two fields
communicating (a little) at last.
Rejuvenation Res 2007; 10(4):637-640.
de Grey ADNJ. Old
people are people too: why it is our duty to fight aging to the
death. Cato Unbound 2007(12): lead essay.
de Grey ADNJ.
Curiosity is addictive, and this is not necessarily a
good thing. Rejuvenation Res 2008;
11(1):1-3.
de Grey ADNJ.
Man, machines, manufacturing and maintenance: merits of a
much-maligned metaphor. Rejuvenation Res
2008; 11(2):277-279.
de Grey ADNJ.
Long live the unreasonable man.
Rejuvenation Res 2008; 11(3):541-542.
de Grey ADNJ.
Combating the Tithonus Error: what works? Rejuvenation Res 2008; 11(4):713-715.
de Grey ADNJ.
Trans-simianism and truthiness: hints of progress in the
debate on whether aging is good.
Rejuvenation Res 2008; 11(5):857-859.
de Grey ADNJ.
Estimating rates of future biomedical progress: a reply to Bains.
Biosci Hyp 2008; 1(5):286.
de Grey ADNJ.
Aging: a foreseeable target of stem cells and
regenerative medicine. World
Stem Cell Report
2008:17-19.
de Grey ADNJ.
Cautionary tales of the unexpected. Rejuvenation Res 2008; 11(6):989-990.
de Grey ADNJ.
Consolidating the mission to defeat aging: a big step
forward. Rejuvenation Res 2008;
11(6):1061-1063.
de Grey ADNJ.
Cracks in social gerontology’s pro-aging
edifice. Rejuvenation Res 2009;
12(1):1-3.
de Grey ADNJ.
The curiously misunderstood role of evidence in designing
new technology. Rejuvenation Res 2009;
12(2):75-76.
de Grey ADNJ.
Why are so many people so unashamedly selfish about the
prospect of combating aging? Rejuvenation
Res 2009; 12(3):165-167.
de Grey ADNJ.
How is mutant mitochondrial DNA clonally amplified? Much
new evidence, still no answers. Rejuvenation
Res 2009; 12(3):217-219.
de Grey ADNJ.
Persons of tenure: less fortunate than they may
seem. Rejuvenation Res 2009;
12(4):237-238.
de Grey ADNJ.
Aging: can piecemeal preventative maintenance
work? World
Stem Cell Report
2009:101-103.
de Grey ADNJ.
The Einsteinian imperative. Rejuvenation Res
2009; 12(6):383-385.
de Grey ADNJ.
Hype and anti-hype in academic biogerontology
research.
Rejuvenation Res 2010; 13(2-3):137-138.
Rae MJ, Butler RN, Campisi J, de Grey
ADNJ, Finch CE, Gough M, Martin GM, Vijg J, Perrott KM, Logan BJ.
The demographic and biomedical case for late-life interventions in
aging. Sci Transl Med
2010;2(40):40cm21.
de Grey ADNJ. Reaping the longevity
dividend in time: biogerontology heavyweights advocate seeking
late-onset interventions against aging. Rejuvenation Res
2010;13(4):383-385.
de Grey ADNJ. Biology: a field in need
of a community culture. Rejuvenation Res
2010;13(5):507-508.
de Grey ADNJ. European Council of Art: a
new initiative to combine both fields and cultures in the pursuit of
visionary goals.Rejuvenation Res
2010;13(6):629-630.
de Grey ADNJ. Premature deaths close to
home. Rejuvenation Res 2011;14(1):1-2.
de Grey ADNJ. Silver linings of
oversimplification. Rejuvenation Res 2011;14(2):109-110.
de Grey ADNJ. The evolution of dogma.
Rejuvenation Res 2011;14(3):239-240.
de Grey ADNJ. Progress... but speed is
of the essence. Rejuvenation Res
2011;14(4):351-352.
de Grey ADNJ. When in doubt, maximize
your options. Rejuvenation Res
2011;14(5):467-468.
de Grey ADNJ. The many-level value of
proofs of concept. Rejuvenation Res
2012;15(2):121-122.
Zealley BJ, de Grey ADNJ. Cancers co-opt
cohabitants' catabolism: Autophagy and senescence in the tumor
stroma. Cell Cycle 2012;11(12):2230.
de Grey ADNJ. Biological versus medical
limits on aging: a distinction we must not elide. Rejuvenation Res
2012;15(3):255-256.
de Grey ADNJ. What's really delaying the defeat of aging?
Rejuvenation Res 2012;15(4):347-348.
de Grey ADNJ. The future dominance of combination
therapies: implications for today's medical research. Rejuvenation
Res 2012;15(5):443-444.
de Grey ADNJ. Dilemmas of discussing dramatic
developments. Rejuvenation Res 2012;15(6):543-544.
- Books:
de Grey
ADNJ. The mitochondrial
free radical theory of aging. Austin, TX: Landes Bioscience, 1999,
212pp, hardcover (ISBN 1-57059-564-X).
de Grey
ADNJ, Rae M. Ending Aging: The
rejuvenation biotechnologies that could reverse human aging in our
lifetime. New York, NY: St. Martin’s Press,
2007, 416pp, hardcover (ISBN 0-312-36706-6). Paperback
edition: St. Martin’s Press, 2008, 448pp (ISBN 0-312-36707-4).
- Book chapters:
de Grey ADNJ. Are
those 13 proteins really unimportable? In: From Symbiosis to
Eukaryotism - Endocytobiology VII (E. Wagner et al., eds.), Geneva
University Press, 1999, pp. 489-502.
de Grey ADNJ.
Mitochondrial mutations in vertebrate aging. In: Oxidative stress
and aging: advances in basic science, diagnostics, and intervention
(R.G. Cutler and H. Rodriguez, eds.), World Scientific Publishing,
2002, pp. 437-451.
de Grey
ADNJ. Mechanisms underlying the age-related accumulation of mutant
mitochondrial DNA. In: Genetics of mitochondrial diseases (I.J.
Holt, ed.), Oxford University Press, 2003, pp.
247-275.
de Grey ADNJ. An
engineer’s approach to the development of real anti-aging medicine.
In: The Fountain of Youth: Ethical, Religious, and Existential
Perspectives on a Biomedical Goal (S.G. Post and R.H. Binstock,
eds.), Oxford University Press, 2004, pp. 249-267.
de Grey ADNJ. The
war on aging. In: The
Scientific Conquest of Death (B.J. Klein et
al., eds.), Libros en Red, 2004, pp. 17-29.
de Grey ADNJ.
Foreseeable and more distant rejuvenation therapies. In: Aging
Interventions and Therapies (S.I.S. Rattan, ed.), World Scientific,
2005, pp. 379-395.
de Grey ADNJ. The foreseeability of real
anti-aging medicine. In: Anti-Aging Medical Therapeutics, volume 7
(R. Klatz, ed.), American Academy for Anti-Aging Medicine, 2005, pp.
59-68.
de Grey ADNJ.
Lysosomal enhancement with microbial hydrolases: a novel strategy
for removing protein aggregates. In: New
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Fisher et al., eds.), Medimond, 2005, pp.
51-54.
de Grey ADNJ. Gene
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Schulz et al., eds.), Springer, 2006, pp. 439-443.
de Grey ADNJ.
Strategie per un invecchiamento transcurabile ingegnerizzato. In:
Alterando il destino dell’umanitŕ (P. Donghi, ed.), Proceedings of
the 2005 Spoletoscienza conference, Laterza & Figli, 2006, pp.
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de Grey ADNJ.
Defeat of aging -
utopia or foreseeable scientific reality? In: The Future of Life and
the Future of our Civilization
(V. Burdyuzha, ed.), Springer, 2006, pp.
277-290.
de Grey ADNJ.
Rejuvenating neurons and glia with microbial enzymes. In:
Interaction Between Neurons and Glia in Aging and Disease (J.O.
Malva et al., eds.), Springer, 2007, pp. 503-510.
de Grey ADNJ.
Endless Youth. In: Eindeloos, 22ste Almanak der Groningse
Farmaceutische Studenten Vereniging “Pharmaciae Sacrum” (I.
Dubbelboer et al., eds.), 2008, pp. 22-27.
de Grey ADNJ.
Postponing aging: re-identifying the experts? In: Unnatural
Selection: the Challenges of Engineering Tomorrow’s People (P.
Healey and S. Rayner, eds.), 2008, pp. 89-94.
de Grey ADNJ.
Radical life extension: technological aspects. In: Religion and the Implications Of Radical Life Extension
(D.F. Maher and C. Mercer, eds.),
Palgrave Macmillan, 2009, pp. 13-24.
de Grey ADNJ. WILT:
necessity, feasibility, affordability. In: The Future of Aging:
Pathways to Human Life Extension (G. Fahy et al., eds.), Springer,
2010, pp. 667-685.
de Grey ADNJ. Physical resilience and aging: correcting
the Tithonus error and the crčme brulée error. In: New Frontiers of
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de Grey ADNJ. Prospects for the biomedical postponement
of aging: technical context for a theological debate. In: The
Routledge Companion to Religion and Science (J.W. Haag, G.R.
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531-539.
de Grey ADNJ.
Living to 100 and maybe much longer: the engineering and
biotechnology of life-extension medicine and when it may arrive. In:
Proceedings of the 6th International Conference on
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de Grey ADNJ. Is
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de Grey ADNJ. Consciousness in the
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Invitations to
speak:
- Seminars:
University of Indiana,
Bloomington, IN, USA, April 1997
University of California,
Riverside, CA, USA, February 1998
University of Newcastle, UK,
October 1998
University of
Linköping, Sweden, May
1999
University of Marburg,
Germany, July 1999
ETH (Eidgenössische Technische Hochschule), Zurich, Switzerland, September 1999
MRC Laboratory of Molecular
Biology, Cambridge, UK, November 1999
MRC Dunn Human Nutrition
Unit, Cambridge, UK, January 2000
University of Washington,
Seattle, WA, USA, June 2000
University of California,
Irvine, CA, USA, October 2000
University of California,
Los Angeles, CA, USA, October 2000
University of Southern
California, Los Angeles, CA, USA, October 2000
Kronos Longevity Research
Institute, Phoenix, AZ, USA, February 2002
University of Southampton,
UK, April 2002
Gray Cancer Institute,
Northwood, UK, September 2002
University of Newcastle, UK,
February 2003
University of California,
Santa Barbara, CA, USA, March 2003
Unilever Research and
Development, Colworth, UK, April 2004
University of Tampere,
Finland, May 2004
ExtroBritannia, Wolverton,
UK, July 2004
CCLRC Daresbury Laboratory,
Warrington, UK, October 2004
University of Birmingham,
UK, November 2004
University of Calgary,
Calgary, AB, Canada, February 2005
University of Alberta,
Edmonton, AB, Canada, February 2005
Baylor College of Medicine,
Houston, TX, USA, March 2005
Rice University, Houston,
TX, USA, March 2005
University of Texas Health
Sciences Center, San Antonio, TX, USA, March 2005
Café Scientifique,
Edinburgh, UK, April 2005
Hunter College, New York,
NY, USA, April 2005
Stanford University,
Stanford, CA, USA, June 2005 (two talks)
University of Utrecht,
Utrecht, The Netherlands, September 2005
London Regenerative Medicine
Network, University College, London, UK, October
2005
University of Cambridge
Institute of Biotechnology, Cambridge, UK, December
2005
Kronos Longevity Research
Institute, Phoenix, AZ, USA, December 2005
People Unlimited,
Scottsdale, AZ, USA, December 2005
Loma Linda University, Loma
Linda, CA, USA, February 2006
Faith, Reason and Community
Forum, Loma Linda, CA, USA, February 2006
Knutsford SciBAr, Knutsford,
UK, February 2006
Demos, London, UK, February
2006
Sierra Sciences, Reno, NV,
USA, February 2006
Corven Corporate Finance,
London, UK, March 2006
University of Cambridge
Medical Society, Cambridge, UK, March 2006
University of Arizona,
Tucson, AZ, USA, April 2006
Arizona State University
Biodesign Institute, Tempe, AZ, USA, April 2006
Yale University, New Haven,
CT, USA, May 2006
Junto, New York, NY, USA,
June 2006
BUPA, London, UK, September
2006
University of Michigan, Ann
Arbor, MI, USA, October 2006
ExtroBritannia, London, UK,
October 2006
The Pensions Net Work,
Maidstone, UK, December 2006
University of Heidelberg,
Heidelberg, Germany, January 2007
Cambridge University Student
Pugwash Society, Cambridge, UK, February 2007
Buck Institute for Age
Research, Novato, CA, USA, March 2007
University of Hohenheim,
Stuttgart, Germany, April 2007
Google, Mountain View, CA,
USA, May 2007
Royal Society of Arts,
London, UK, June 2007
Google, Mountain View, CA,
USA, June 2007
San Francisco Future Salon,
Palo Alto, CA, USA, July 2007
Cambridge Hi-tech
Association of Small Enterprises, Cambridge, UK, August
2007
British Humanist
Association, London, UK, August 2007
University of California
Berkeley, Berkeley, CA, USA, October 2007
Oxford University Science
Society, Oxford, UK, October 2007
Sangamo Sciences, Richmond,
CA, USA, October 2007
Milner Society (Queens’
College Cambridge), Cambridge, UK, November 2007
Case Western Reserve
University, Cleveland, OH, USA, November 2007 (two
talks)
Royal College of Arts,
London, UK, November 2007
Google, Mountain View, CA,
USA, December 2007
Bangor SciBAr, Bangor, UK,
January 2008
Dana Centre, London, UK,
January 2008
Trinity College Science
Society, Cambridge, UK, January 2008
University of Pennsylvania,
Philadelphia, PA, February 2008
New York University, New
York, NY, USA, February 2008
Cass Business School,
London, UK, February 2008
Cambridge Young Solicitors
and Professionals Group, Cambridge, UK, February
2008
St Paul’s School, London,
UK, March 2008
Spirit of the Senses,
Phoenix, AZ, USA, March 2008
University of Wisconsin,
Madison, WI, USA, April 2008
Orlando Science Center,
Orlando, FL, USA, May 2008
Proctor & Gamble
workshop “Future thinking”, New York, NY, USA, June
2008
University of Alberta,
Edmonton, Canada, June 2008
The Pensions Net Work,
Hurley, UK, June 2008
Toronto Public Library
Network, Toronto, Canada, June 2008
ExtroBritannia, London, UK,
July 2008
University of Hull, Hull,
UK, July 2008
Café Scientifique,
Lichfield, UK, July 2008
The Motley Fool, Alexandria,
MD, USA, July 2008
Google, New York, NY, USA,
July 2008
UCLA student group “POLIS”,
Los Angeles, CA, USA, August 2008
NuSkin, Provo, UT, USA,
August 2008
NASA Ames Research Center,
Mountain View, CA, UA, August 2008
Think Tank der Bank Sarasin
& Cie, Zurich, Switzerland, September 2008
Kronos Longevity Research
Institute, Scottsdale, AZ, USA, September 2008
University of Ghent, Ghent, Belgium, October
2008
Jewish Community Center of
San Francisco, San Francisco, CA, USA, October
2008
Stanford Transhumanist
Association, Palo Alto, CA, USA, October 2008
The Nature
Debate, London, UK, November 2008
Spirit of the Senses,
Phoenix, AZ, USA, December 2008
HEALES, Narbonne, France,
January 2009
Caixa
Foundation, Lleida, Spain, January 2009
Caixa
Foundation, Barcelona, Spain, January
2009
Caixa
Foundation, Madrid, Spain, January 2009
University
of Palma, Palma, Mallorca, January 2009
Caixa
Foundation, Tarragona, Spain, January
2009
Kent State
University, Kent, OH, USA, February
2009
University
of Manchester, Manchester, UK, February
2009
University
of Liverpool, Liverpool, UK, February
2009
Moscow
State University, Moscow, Russia, March
2009
University
of Westminster, London, UK, March 2009
University
of Ghent, Ghent, Belgium, March 2009
Bank
Sarasin & Cie, Interlaken, Switzerland, April
2009
Queen Mary University of
London, London, UK, April 2009
Smart Life Forum, Palo Alto,
CA, USA, May 2009
Commonwealth Club, San
Francisco, CA, USA, May 2009
University of Leicester,
Leicester, UK, June 2009
Singularity University,
Mountain View, CA, USA, July 2009
Summer Science Program,
Ojai, CA, USA, July 2009
Skeptics in the Pub, London,
UK, August 2009
Kings Fund, London, UK,
September 2009
New York Academy of
Sciences, New York, NY, USA, September 2009
Silicon Valley Transhumanist
Meetup, Palo Alto, CA, USA, September 2009
The Commonwealth Medical
College, Scranton, PA, USA, September 2009
UK Transhumanist
Association, London, UK, October 2009
Oxford University Science
Society, Oxford, UK, October 2009
Karolinska Institute,
Stockholm, Sweden, October 2009 (two talks)
Osher
Lifelong Learning Institute, Saginaw, MI,
USA, November 2009
NHS Workforce Review Team,
Winchester, UK, December 2009
Haberdashers’ Aske’s Boys’
School, Elstree, UK, January 2010
Wellcome Trust, London, UK,
January 2010
Staffordshire University,
Stafford, UK, March 2010
Omega Institute, Rhinebeck,
NY, USA, October 2010
- National and international
meetings:
Endocytobiology VII,
Freiburg, Germany, April 1998
4th European
Congress of Gerontology, Berlin, Germany, July
1999
Euromit 4, Cambridge, UK,
September 1999
Symposium: stress and ageing
in animals and microorganisms, Porto, Portugal, June
2000
BBSRC Science of Ageing
symposium, Manchester, UK, January 2001
O2SA (Oxidative Stress in
Aging), 2nd Conference, Maui, HI, USA, April
2001
International Association of
Biomedical Gerontology, 9th Congress, Vancouver, Canada,
June 2001
27th Meeting of
FEBS, Lisbon, Portugal, July 2001
Warburg Society, inaugural
conference, Point Clear, LA, USA, October 2001
6th International
Conference on Plasma Membrane Redox Systems, Ravenna, Italy, March
2002
Mechanisms of Caloric
Restriction conference, Bandera, TX, USA, October
2002
3rd European
Congress of Biogerontology pre-meeting, San Miniato, Italy, November
2002
5th Alcor
Conference on Extreme Life Extension, Newport Beach, CA, USA,
November 2002
Foresight Institute 2003
Senior Associates Gathering, Palo Alto, CA, USA, May
2003
Transvision 2003, Yale
University, New Haven, CT, USA, June 2003
CMIB symposium “Projecting
Future Mortality”, Edinburgh, UK, October 2003
Pop!Tech 2003 conference
“Sea Change”, Camden, ME, USA, October 2003
7th International
Conference on Plasma Membrane Redox Systems, Asilomar, CA, USA,
April 2004
Pittsburgh symposium
“Frontiers in Human Embryonic Stem Cells”, Pittsburgh, PA, USA, May
2004
3rd Medical and
Aesthetic Procedures Meeting, Barcelona, Spain, June
2004
3rd Asia Pacific
Conference and Exhibition on Anti-Ageing Medicine, Singapore, June
2004
Transvision 2004, Toronto,
Canada, August 2004
1st Anti-Ageing
Conference London, London, UK, September 2004
German Society of
Gerontology and Geriatrics, 7th Congress, Hamburg,
Germany, October 2004
5th Neurobiology
of Aging symposium, San Diego, CA, USA, October
2004
Integrative Medical
Therapeutics for Anti-Aging conference, Las Vegas, NV, USA, October
2004
EMBL/EMBO conference on
Science and Society, Heidelberg, Germany, November
2004
Futurshow 3004, Milan,
Italy, November 2004
12th Annual World
Congress on Anti-Aging Medicine, Las Vegas, NV, USA, December
2004
BIOMEDEX 2005, Montreal,
Canada, March 2005
IHEU-Appignani Humanist
Center for Bioethics, 1st Conference, New York, NY, USA,
April 2005
2nd “The
future of life and the future of our civilization”
symposium, Frankfurt, Germany, May 2005
2nd Anti-Ageing
Conference London, London, UK, May 2005
Workshop on Models in the
Biodemography of Aging, Berkeley, CA, USA, June
2005
FENS Summer School, Coimbra,
Portugal, July 2005
TEDGLOBAL (Technology,
Entertainment, Design) conference, Oxford, UK, July
2005
17th
SpoletoScienza conference “Altering Human Destiny”, Spoleto, Italy,
July 2005
Eris Society,
25th annual conference, Aspen, CO, USA, August
2005
International Association of
Biomedical Gerontology, 11th Congress, Aarhus, Denmark,
August 2005
10th Future of
Health Technology Summit, Cambridge, MA, USA, September
2005
4th RNAO
International Elder Care Conference, Toronto, Canada, September
2005
Conservative Party
Conference 2005, Blackpool, UK, October 2005
Louis Vuitton Moet Hennessy
symposium on mitochondria, Paris, France, October
2005
European Society for
Cosmetic & Aesthetic Dermatology Society Mtg., London, UK,
October 2005
Foresight Institute 2005
Vision Weekend, San Francisco, CA, USA, October
2005
Immortality Institute,
1st Conference, Atlanta, GA, USA, November
2005
58th Annual
Meeting, Gerontological Society of America, Orlando, FL, USA,
November 2005
Nordic Exceptional Trendshop
2005, Copenhagen, Denmark, November 2005
22nd Human
Genetics Commission Plenary Meeting, November 2005
9th Goodenough
conference ‘Age & Ageing: Just the Concern of the Old?’, London,
UK, Dec. 2005
AAAS Annual Meeting, St.
Louis, MO, USA, February 2006
TED (Technology,
Entertainment, Design) 2006, Monterey, CA, USA, February
2006
Vodafone Foundation
symposium, Madrid, Spain, March 2006
1st World Forum
on Science and Civilisation, Oxford, UK, March
2006
1st Berkeley Stem
Cell Retreat, Asilomar, CA, USA, March 2006
Calorie Restriction Society,
4th Conference, Tucson, AZ, USA, April
2006
Human
Enhancement Technologies and Human Rights, Stanford, CA, USA, May
2006
Transvision 2006, Helsinki,
Finland, August 2006
1st ENHANCE
Workshop on the Extension of Lifespan, Cesano Maderno, Italy,
September 2006
5th European
Congress of Biogerontology, Istanbul, Turkey, September
2006
2nd Women’s Forum for the Economy and Society,
Deauville, France, October 2006
6th Alcor
Conference on Extreme Life Extension, Scottsdale, AZ, USA, October
2006
Living Well to 100,
2nd Conference, Boston, USA, November
2006
3rd World Mystery
Forum, Interlaken, Switzerland, November 2006
American Academy of Religion, 2006 Annual Meeting,
Washington, DC, USA, November 2006
Rome
Science Festival, Rome, Italy, January
2007
London Technology Network:
Stem Cells and Regenerative Medicine, London, UK, March
2007
Edmonton
Aging Symposium, Edmonton, Canada, March 2007
UBS Global
Investors’ Forum, London, UK, April
2007
German
Society of Anti-Aging Medicine, 7th Conference, Munich,
Germany, May 2007
2nd ENHANCE
Workshop on the Extension of Lifespan, Cesano Maderno, Italy, May
2007
International Association of
Biomedical Gerontology, 12th Congress, Spetses, Greece,
May 2007
6th Cheltenham
Science Festival, Cheltenham, UK, June 2007
6th Intl. Conf. on Intelligent Processing and
Manufacturing of Materials, Salerno, Italy, June
2007
Oxford
Conference on Genetics and Justice, Oxford, UK, July
2007
National
Council for Palliative Care, 15th Anniversary Symposium,
London, UK, July 2007
CEPS symposium “Europe
facing ageing - economic perspectives”, Prague, Czech Rep., July
2007
Institute for Ethics and
Emerging Technologies symposium, Chicago, IL, USA, July
2007
Transvision 2007, Chicago,
IL, USA, July 2007
Secret Garden Party, Kings
Ripton, UK, July 2007
4th Anti-Ageing
Conference London, London, UK, September 2007
12th Future of
Health and Technology Institute Conference, Cambridge, MA, USA,
September 2007
Gadgetoff, New York, NY,
USA, September 2007
7th Alcor
Conference on Extreme Life Extension, Scottsdale, AZ, USA, October
2007
3rd European Anti-Aging Congress, Paris, France,
October 2007
8th Asia/Oceania Regional Congress of
Gerontology & Geriatrics,
Beijing, China, October 2007
American
Academy of Religion, 2007 Annual Meeting, San Diego, CA, USA,
November 2007
Hewitt’s Local Government
Pension Service symposium, London, UK, January
2008
Future of
GI Health Summit, Boston, MA, USA, January
2008
BIL 2008,
Monterey, CA, USA, March 2008
Center for
Bioethics & Human Dignity, 1st Annual Phoenix Conf.,
Phoenix, AZ, USA, March 2008
Anti-Aging Medicine World
Congress, Paris, France, April 2008
34th Asilomar
Microcomputer Workshop, Asilomar, CA, USA, April
2008
Seoul Digital Forum, Seoul,
Korea, May 2008
ERBI’s 10th Annual
BioPartnering Exchange, Hinxton, UK, May 2008
Hewlett-Packard Worldwide
Health and Life Sciences Symposium, Orlando, FL, USA, May
2008
Italian Academy of
Anti-Aging Medicine, 3rd National Congress, May
2008
Life Link conference,
Gleneagles, UK, May 2008
Thinking Digital, Gateshead,
UK, May 2008
Anti-Ageing Skin Care
Conference 2008, London, UK, June 2008
IdeaCity08, Toronto, Canada,
June 2008
BioBarCamp, Mountain View,
CA, USA, August 2008
SciFoo, Mountain View, CA,
USA, August 2008
European Congress on
Anti-Aging and Aesthetic Medicine, Dusseldorf, Germany, September
2008
13th Future of
Health and Technology Institute Conference, Cambridge, MA, USA,
September 2008
International Workshop on
postponing ageing, Tallinn, Estonia, October 2008
2008 Conference of the
Libertarian Alliance, London, UK, October 2008
4th European
Futurists Conference, Lucerne, Switzerland, October
2008
The Future, Hamburg,
Germany, October 2008
Summit on the Global Agenda,
Dubai, November 2008
Changing the World, Toronto,
Canada, November 2008
Convergence ‘08, Mountain
View, CA, USA, November 2008
ASU workshop on the systems
biology of aging, Tempe, AZ, USA, December 2008
BIL 2009,
Monterey, CA, USA, February 2009
Workshop on
Anti-Aging Medicine, Volterra, Italy, March
2009
4th World
Congress of Regenerative Medicine, Bangkok, Thailand, March
2009
Eisai
Symposium in Neuroscience, London, UK, April
2009
International Association of
Biomedical Gerontology, 13th Congress, Montreal, Canada,
May 2009
Metanexus Conference,
Phoenix, AZ, USA, July 2009
Life Aid, Brussels, Belgium,
September 2009
World Stem Cell Summit,
Baltimore, MD, USA, September 2009
Glenn Foundation Symposium
on the Biology of Aging, Cambridge, MA, USA, September
2009
14th Future of
Health Technology Summit, Cambridge, MA, USA, September
2009
IQPC Life Settlements
Summit, New York, NY, USA, October 2009
Singularity Summit, New
York, NY, USA, October 2009
2nd European
Conference on Anti-Aging and Aesthetic Medicine, Mainz, Germany,
October 2009
Women’s Forum Global
Meeting, Deauville, France, October 2009
Brocher Foundation
symposium, Geneva, Switzerland, October 2009
TED MED 2009, San Diego, CA,
USA, October 2009
BIL:PIL, San Diego, CA, USA,
October 2009
Manhattan Beach Project,
Manhattan Beach, CA, USA, November 2009
UK Society of Cosmetic
Scientists, London, UK, December 2009
Systems biology of aging,
2nd annual conference, Baltimore, MD, USA, December
2009
LIFT, Geneva, Switzerland,
May 2010
Anti-Aging Medicine
conference, Lisbon, Portugal, May 2010
American Aging Association,
Portland, OR, USA, June 2010
World Future Society,
Boston, MA, USA, July 2010
European Respiratory
Society, Barcelona, Spain, September 2010
Our Common Future, Essen,
Germany, November 2010
